CRONILIEF™, THE NEW HEALTH FOOD INGREDIENT FOR AN ACHE-FREE HEALTHY LIFE

CRONILIEF™ (PEA Indena Phytosome™) is an innovative health-food ingredient based on the natural “PEA” (Palmitoylethanolamide) compound formulated with Indena Phytosome™ technology to optimize its bioabsorption and performance in addressing ache management. The use of supplements for managing chronic ache has become an increasingly popular approach, as many individuals seek alternatives to traditional treatments. Chronic ache is often associated with aging-related conditions such as osteoarthritis, neuropathic and musculoskeletal disorders, and can be challenging to manage with conventional medications alone, due to side effects, risk of addiction and limited effectiveness: being an individual and subjective experience, chronic ache needs for a multiple approach, and food supplements can meet the need for a holistic support thanks to the use of natural compounds able to help alleviate ache and reduce inflammation, but also to improve overall quality of life in people dealing with long-term discomfort during the natural ageing process. In this scenario, PEA is natural lipid compound, specifically an endogenous fatty acid amide, produced in the body and known to play a key role in regulating inflammation and ache responses. Thanks to the so-called entourage effect, PEA works on multiple natural pathways positively linked to the modulation of the endocannabinoid system, influencing targets and receptors involved in the inflammatory response and in ache signaling. Unfortunately, the oral supplementation with traditional PEA is weakly effective due to its poor oral bioavailability, which hampers this ingredient from reaching the desired health benefits. The lipophilic nature of PEA presents a major challenge, but Indena Phytosome ™ technology comes to the aid to exploit PEA potential. Indena Phytosome™ is a solid dispersion of botanicals or natural compounds into a 100% food-grade matrix based on lecithin, amphipathic molecules which act as inhibitor of self-aggregation and wetting agents. Indena Phytosome™ allows natural compounds to efficiently interact with the gut ecosystem in terms of absorption and microbiota interactivity, without relying on pharmacological adjuvants or structural modification of the ingredients, maintaining tolerability and safety over time. In CRONILIEF™, PEA natural compound gets all the advantages from Indena Phytosome™ delivery system. Thanks to the formulation in the lecithin-based solid dispersion, CRONILIEF™ is shown to improve PEA solubility in gastrointestinal simulated fluids by 8 times compared to both traditional and fine powder PEA ingredients respectively.These results and multiple human studies pave the way to the use of CRONILIEF™ as promising adjuvant to ache management, being the natural innovation that health-food consumers were looking for. Join Indena to discover more about CRONILIEF™, a new promising, safe, and effective solution for relief from chronic discomforts.

Lingua della presentazione: Italiano